Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here. we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Current cancer ICB benefits only a small subset of patients. https://www.roneverhart.com/Akaada-Platform-Penny-Loafers-Yoko-Ivory-Patent-Leather-Size-36-NEW/