Summary: Single-cell transcriptomics suffer from sensitivity limits that restrict low abundance transcript identification. affects clustering and can hamper downstream analyses. Here. we describe Constellation sequencing (Constellation-Seq). https://www.roneverhart.com/Western-Digital-Ultrastar-DC-HC570-WUH722222ALE6L1-22TB-7-2K-RPM-SATA-6Gb-s-512e-SED-3-5in-Recertified-Hard-Drive/